New Procedure for Acute Suicidal Ideation and Behavior

If accredited, SLS-002 would be only the 2nd accepted solution for ASIB.

The to start with patient has been dosed in the second aspect of Seelos Therapeutics’ registrational research of their formulation of intranasal racemic ketamine (SLS-002) for acute suicidal ideation and behavior (ASIB) in sufferers with key depressive problem (MDD).

“There is a significant unmet need to have inside of the MDD market place for pharmacotherapies that can show immediate antidepressant consequences, in specific for people with significant MDD requiring hospitalization which include people with ASIB. In component 1 of the analyze, SLS-002 confirmed significant improvement in depressive indications at 24 several hours compared to placebo,” claimed Philippa Salter, Neurology Analyst at GlobalData.1

If accredited, SLS-002 would develop into the second product or service accepted specifically for ASIB. The initially products, Johnson & Johnson’s fast-acting esketamine (Spravato), was accredited for reasonable-to-severe MDD individuals with ASIB in 2020. Because of to hazard of sedation and disassociation, Spravato is only out there by means of a restricted system.

“Although Spravato was a breakthrough therapy for ASIB, its significant charge of remedy, and necessity for 2 hours of individual observation immediately after administration will also restrict its uptake,” Salter ongoing. “As a similar compound, and with the similar intranasal route of administration, it is achievable that SLS-002 will encounter identical troubles to Spravato. Having said that, in a smaller, randomized demo intranasal ketamine brought about minimal dissociative outcomes, which, if replicated in larger sized trials, would give SLS-002 an gain about Spravato.”1

Many rapid-acting antidepressants are searching to enter the market place, which include the subsequent late-phase goods: Sage Therapeutics/Biogen’s zuranolone (SAGE-217) Axsome Therapeutics’ bupropion and dextromethorphan (AXS-05) and Relmada Therapeutics’ REL-1017. When these merchandise are not specifically in advancement for ASIB, if they reveal powerful efficacy for MDD, a label growth could be sought in the long term.


1. GlobalData. Seelos Therapeutics’ SLS-002 could be a sturdy competitior to Spravato for treatment of suicidal habits, suggests GlobalData. Information release. July 13, 2021. Accessed July 16, 2021.

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